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Vacuum drying oven For small and medium pilot production Vacuum drying oven is an older drying device. The heated plate in the box is divided into several layers. The hot plate or the low-pressure steam is used as the heating medium in the heating plate, and the tray plated with the medicine to be dried is placed on the heating plate, the door is closed, the box is pumped with a vacuum pump, and the heating plate circulates the medicine in the circulating flow of the heating medium. When heated to the specified temperature, the water starts to evaporate and gradually withdraws with a vacuum.
This equipment is easy to control, can condense and recover the evaporated solvent, and the drug can not be contaminated during the drying process. It can be used for drying medicines, sterilization of packaging materials and heat treatment. In the 1980s, the bulk drug industry used this device as the main dryer. However, due to the difficulty in online cleaning (CIP) and on-line sterilization (SIP) of the tray, the drying speed was slow, the labor intensity of the workers was large, and the drugs were realized. Uniformity, even after mixing by powder mixing device after drying, it has been rarely used in large-scale production of raw material medicine, and it is mostly used for medium and small trial production or heat treatment of packaging materials.
Vacuum rotary dryer must consider the hollow shaft sealing effect Vacuum rotary dryer from the double cone mixer, mostly cylindrical body, two-cone, also known as double cone dryer. There are two hollow suspension shafts in the middle of the cone to support the rotation of the equipment and the passage of vacuum and hot water. The medicines rotate while drying in the desiccator, which ensures good uniformity of the whole batch of medicine. The heat medium enters the jacket from a hollow tube at one end, and the hot gas in the apparatus is exhausted with the exhaust pipe in the hollow tube at the other end, and the volatilized solvent is recovered through condensation. This equipment was developed by the Shanghai Pharmaceutical Industry Research Institute in the 1980s and successfully tested on penicillin production. It was quickly promoted in the national antibiotic industry. There are many domestic manufacturers. Later, the uniaxial rotary dryer multi-dimensional rotary dryer, inclined rotary dryer and similar products appeared. This equipment is equipped with a vacuum system, solvent recovery system, cleaning and sterilization systems.
Due to its simple operation, intermittent production, easy adjustment, on-line cleaning and on-line sterilizing, this device has become the preferred dryer for small and medium-sized antibiotics drug companies, such as penicillin, lincomycin, chlortetracycline, and caffeine. Choose. When selecting the equipment, the concentricity of the two hollow shafts and the sealing of the hollow shaft are mainly considered. In order to ensure a stable operation of the equipment, the concentricity requires that the axial runout be less than 0.01 mm. The sealing effect of the hollow shaft is mainly to prevent the lubricant or filler from contaminating the medicine. .
Three-in-one equipment The quality of domestic equipment needs to be improved Three-in-one means that the three processes of filtration, washing, and drying are combined in the same equipment, which is very representative in the pharmaceutical industry. Three-in-one equipment has developed rapidly since the 1990s, and is divided into belt type, tank type, and centrifugal type according to the type of equipment.
Belt type three-in-one has two kinds of step type and continuous type, mainly because the filter belt has different advancement methods. The same work flow is uniformly placed on the filter belt by the feeder, and the filter belt is dragged by the transmission device in the dryer. Move inside. In the washing and filtering section, the solvent is washed, and the solvent mother liquor is vacuum-cooled to recover the solvent; the hot air in the drying section enters, and the vacuum is removed and condensed to recover the solvent. For mass production batch production, suitable for drying of particles with good air permeability, and the finished product is evenly dried. It is widely used in the vitamin C and penicillin industries in China. Due to the relatively poor tightness of this equipment, online cleaning and online sterilization cannot be well arranged, so it is only suitable for the drying of non-sterile APIs and pharmaceutical intermediates. This device feeder and filter belt correction device play a key role in the normal operation of the equipment. In addition, supporting facilities such as heaters and vacuum systems also have a great influence on the equipment yield.
Such equipment used in the pharmaceutical industry is mainly imported or self-assembled with imported major components. Domestically produced equipment of this type is used only in chemical and food medicine and other industries. In recent years, companies in the pharmaceutical industry also have imitations, but have succeeded in the pharmaceutical industry. Applications are rare.
The tank of the three-in-one tank is similar to a large-sized suction filter. The chassis is composed of a metal sintered plate screen, a supporting plate and a heating plate. The tank body has a jacket for heating and cooling, and the tank has stirring that can move up and down. The agitator is a hollow structure that is passed through a medium for heating and cooling and plays a major role in the drying stage. After the material enters the equipment, it shall be filtered by suction, then added to the washing medium for a certain period of time, cold or pressure filtered to a certain extent, the stirring, the chassis, and the jacket shall be passed into the heating medium at the same time, and vacuum shall be used for drying. According to experience and sampling Stop drying after passing and discharge from the discharge port. Stirring and sintering plates for this equipment are the most critical, and supporting equipment includes hydraulic systems, vacuum systems, heating and cooling units. Because this equipment is fully enclosed, if the automatic discharge system is added, the equipment can be fully CIP and SIP, so it is very suitable for the production of sterile bulk drugs.
Reasonable selection of drying equipment to improve the efficiency of raw material drying (1)
In recent years, the importing countries of raw material medicines have put forward higher requirements for the production process of pharmaceutical companies in China. Therefore, various certifications are rapidly launched in the pharmaceutical industry. For APIs, the focus of these certifications is on the fine, dry, and packaged positions, so the proper selection of dryers is particularly important. The selection of drying equipment depends on the characteristics of the product and the desired state of the finished product. In particular, the material and sterility of the sterile raw material drying equipment must be considered. At present, there are many types of raw material dryers in China, and their respective characteristics and application conditions are different.